Cells of immune system Lymphocytes, phagocytic cell, granulocytes and dendritic cells

Cells of immune system: Lymphocytes, phagocytic cell, granulocytes and dendritic cells

Introduction

The immune system is the body’s natural defense against harmful invaders like bacteria, viruses, and parasites. It relies on several specialized cells to detect, destroy, and remove these threats. These immune system cells can be grouped into four main types: lymphocytes, phagocytic cells, granulocytes, and dendritic cells. Each plays a unique and essential role in maintaining the body’s health.

Lymphocytes

Lymphocytes are a type of white blood cell central to the adaptive immune system, which learns to recognize and remember specific pathogens. The three main types of lymphocytes are:

B cells

B cells produce antibodies, which are proteins that attach to specific antigens (foreign substances) to neutralize them. Each B cell creates a distinct antibody that targets a specific pathogen. When a pathogen enters the body, the relevant B cell is activated, producing large quantities of antibodies to fight the infection. B cells also have a memory function, allowing for a faster response if the same pathogen attacks again.

T cells

T cells come in two main types: helper T cells and cytotoxic T cells. Helper T cells orchestrate the immune response by activating other immune system cells, such as B cells and phagocytes, and releasing cytokines (chemical signals) to regulate immune activity. Cytotoxic T cells, meanwhile, directly destroy infected or cancerous cells. Like B cells, T cells can remember pathogens they’ve previously encountered, enabling a quicker response upon re-infection.

Natural Killer (NK) cells

Part of the innate immune system, NK cells are the body’s first line of defense. They detect and kill virus-infected or abnormal cells, like cancer cells, without needing prior exposure to the pathogen, unlike B and T cells, which rely on recognizing specific antigens.

Phagocytic Cells

Phagocytic cells, a key part of the innate immune system, work by “eating” (phagocytosing) harmful invaders and cellular debris. The two main phagocytic cells are:

Macrophages

Large cells that patrol body tissues, engulfing pathogens and debris. Macrophages are highly adaptable and can change their activity based on the situation. In addition to their role in phagocytosis, they help trigger the adaptive immune system by displaying pieces of pathogens (antigens) to T cells, which stimulates a targeted immune response.

Neutrophils

The most common type of white blood cell, neutrophils act as first responders to infections, especially bacterial infections. They travel quickly to the site of infection, engulf pathogens, and release enzymes to destroy them. Though they are short-lived and often die after attacking pathogens, neutrophils release chemicals that continue to fight infections even after they die.

Both macrophages and neutrophils play vital roles in removing harmful invaders and cleaning up tissue to support healing.

Granulocytes

Granulocytes are a group of white blood cells that contain granules, or small packets filled with enzymes and other chemicals that help combat infections. The three types of granulocytes are:

Eosinophils

Primarily involved in fighting parasitic infections, eosinophils release toxic proteins and other chemicals to kill parasites. They also play a role in allergic reactions and can cause tissue damage if over-activated, as seen in conditions like asthma.

Basophils

The least common type of granulocyte, basophils are involved in inflammatory and allergic responses. When they encounter allergens, they release histamine and other substances that cause inflammation. Like eosinophils, basophils also help defend against parasites.

Neutrophils

Neutrophils, which are also granulocytes, contain granules filled with enzymes that help them destroy pathogens. These granules release chemicals that attack microbes during infection.

Dendritic Cells

Dendritic cells act as a bridge between the innate and adaptive immune systems. Found in tissues that are exposed to the external environment, such as the skin and mucous membranes, dendritic cells capture pathogens and break them down into smaller fragments (antigens). These antigens are then presented to T cells, helping to activate the adaptive immune response. By showing T cells what the pathogen looks like, dendritic cells kick-start the body’s targeted defense mechanisms.

Summary

These different types of immune cells work together to protect the body. Lymphocytes provide targeted defenses against specific pathogens and remember them for future attacks. Phagocytic cells, like macrophages and neutrophils, act as the body’s cleanup crew, engulfing pathogens and dead cells. Granulocytes, particularly eosinophils and basophils, are essential in fighting parasites and managing inflammation, while dendritic cells help initiate the adaptive immune response by presenting antigens to T cells. Collectively, these cells form a coordinated defense system, ensuring the body stays healthy and resilient against infections.

Frequently Asked Questions (FAQ)

Define about immune system cells ?

Immune system cells, also called immune cells, are specialized white blood cells that play a crucial role in defending the body against infections, diseases, and harmful invaders like bacteria, viruses, and parasites.

Define invaders?

Invaders are external threats, such as bacteria, viruses, or parasites, that enter the body and may lead to illness or infection.

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